Xiao Lab

My primary research interest is to understand the molecular mechanisms of dietary fat digestion by pancreatic lipases in young children to improve fat digestion for better growth and development. My secondary research interest is to define the role of proteotoxicity in the pathophysiology of chronic pancreatitis using mutant misfolded pancreatic lipases as study model for finding potential novel therapies.

Principal investigator

Xunjun Xiao, PhD

Assistant Professor of Pediatrics, Gastroenterology, Hepatology & Nutrition

• Phone: 314-454-6173

Recent publications

• Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas
  June 1, 2024
  Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreasBrekke, R. S., Gravdal, A., El Jellas, K., Curry, G. E., Lin, J., Wilhelm, S. J., Steine, S. J., Mas, E., Johansson, S., Lowe, M. E., Johansson, B. B., Xiao, X., Fjeld, K. & Molven, A., Jun 1 2024, In: Human molecular genetics. 33, 11, p. 1001-1014 14 p.Research output: Contribution to journal › Article › peer-review
• Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort
  June 1, 2024
  Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohortCassidy, B. M., Jiang, F., Lin, J., Chen, J. M., Curry, G. E., Ma, G. X., Wilhelm, S. J., Deng, S. J., Zhu, G., Liao, Z., Lowe, M. E., Xiao, X. & Zou, W. B., Jun 2024, In: Pancreatology. 24, 4, p. 511-521 11 p.Research output: Contribution to journal › Article › peer-review
• Characterization of novel PNLIP variants in congenital pancreatic lipase deficiency
  December 1, 2023
  Characterization of novel PNLIP variants in congenital pancreatic lipase deficiencyLin, J., Matiwala, N., Curry, G. E., Wilhelm, S. J., Cassidy, B. M., Lowe, M. E. & Xiao, X., Dec 2023, In: Pancreatology. 23, 8, p. 1036-1040 5 p.Research output: Contribution to journal › Article › peer-review
• Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis
  July 1, 2023
  Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitisZhu, G., Wilhelm, S. J., George, L. G., Cassidy, B. M., Zino, S., Luke, C. J., Hanna, M., Stone, S., Phan, N., Matiwala, N., Ballentine, S. J., Lowe, M. & Xiao, X., Jul 1 2023, In: Gut. 72, 7, p. 1340-1354 15 p.Research output: Contribution to journal › Article › peer-review
• The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice
  December 1, 2022
  The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in miceFjeld, K., Gravdal, A., Brekke, R. S., Alam, J., Wilhelm, S. J., El Jellas, K., Pettersen, H. N., Lin, J., Solheim, M. H., Steine, S. J., Johansson, B. B., Njølstad, P. R., Verbeke, C. S., Xiao, X., Lowe, M. E. & Molven, A., Dec 2022, In: Pancreatology. 22, 8, p. 1099-1111 13 p.Research output: Contribution to journal › Article › peer-review